Endocrine Abstracts

Introduction: Endogenous Cushing syndrome (CS), is associated with significant morbidity (metabolic, cardiovascular, bone, psychiatric complications among others). Most complications tend to improve if hypercortisolism is controlled but some are only partially reversible or even experience temporary exacerbation.Patients and Methods: We report 2 cases of adrenal Cushing Syndrome (CS). The first is a 72 years-old female with CS caused by bilateral macrono...

Background: Cushing’s disease is characterized by chronic ACTH hypersecretion, leading to hyperplasia of the adrenal zonae reticularis and fasciculata and, therefore, increased secretion of cortisol, androgens and DOC. Cushing’s disease is the most common form of Cushing’s syndrome, being responsible for approximately 80% of reported cases.Aim: To evaluate the curability rate of Cushing’s disease 1 year postoperatively.<p clas...

Introduction: Paraneoplastic Cushing’s syndrome is attributed to ectopic ACTH release from a non-pituitary tumor. The lung is frequently the primary site of the underlying neoplasm but sometimes, in cases of advanced metastatic disease, determining the origin may be challenging.Case presentation: A70-year-old man was reffered to our centre for generalised bone pain, lethargy, and important weight loss in the last six months. Before admission, a cont...

Introduction: Insulinoma is a rare tumor that causes spontaneous fasting hypoglycemia in a supposedly healthy adult. Mostly these tumors are single and benign, few are malignant and a minority is represented by multiple adenomas. The treatment of choice is surgical removal of the insulinoma, which cures the condition in the majority of cases. However, after performing the surgery, less than 10% of patients either develop diabetes mellitus or continue to have persistent hypogly...

IntroductionPituitary apoplexy is a rare entity characterized by abrupt hemorrhage and/or ischaemia of the constituents of sella turcica. It usually occurs in a previously unsuspected pituitary tumor. It may have an acute or subclinical presentation and it may represent a neuroendocrinological emergency.AimThis study aims to analyze predisposing or precipitating factors, clinical status, imaging and hormonal ...

Background and objective: The purpose of this study was to retrospectively analyse the clinical, imaging and hormonal features, as well as the therapeutic outcomes in a series of consecutive patients presenting with pituitary apoplexy (PA).Design: We retrospectively reviewed 71 case-records of patients with PA admitted during 2019 in a single tertiary endocrinology center.Results: ...

Introduction: Pheochromocytoma is an adrenal medullary tumor which typically involves nonspecific symptoms like arterial blood hypertension, tachycardia, headache or sweating. In some cases, patients may be completely asymptomatic at onset and exceptionally develop symptoms after surgery.Case presentation: We present two cases, first one of a 36 years old male, in which an MRI scan for evaluation of the spine revealed an oval, well-contoured heterogeneou...

Introduction: The term “pituitary apoplexy” (PA) describes the appearance of abrupt hemorrhage and/or ischaemia of the constituents of sella turcica, usually in a pre-existing pituitary tumor. The presentation of this syndrome may be acute or subclinical.Objective: This study aims to assess clinical, imaging and hormonal features and the outcomes following surgery or conservative treatment among pituitary adenoma patients presenting with PA.</p...